Publications

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Assessment of Human Islet Grafts in Frozen Sections of CD-1 Athymic nu/nu Mouse Liver for Molecular Analysis

Hasilo CP, Negi S, Gasparrini M, Paraskevas S.
Transplant Proc. 2014 Jul-Aug;46(6):1956-9.
PMID: 25131081
 

GABA promotes human β-cell proliferation and modulates glucose homeostasis

Purwana I, Zheng J, Li X, Deurloo M, Son DO, Zhang Z, Liang C, Shen E, Tadkase A, Feng ZP, Li Y, Hasilo C, Paraskevas S, Bortell R, Greiner DL, Atkinson M, Prud'homme GJ, Wang Q.
Diabetes. 2014 Jul 9.
PMID: 25008178
 

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

Christensen DP, Gysemans C, Lundh M, Dahllöf MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N,
Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T.
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1055-9.
PMID: 24395784 
 

GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone

Prud'homme GJ, Glinka Y, Hasilo C, Paraskevas S, Li X, Wang Q.
Transplantation. 2013 Oct 15;96(7):616-23. 
PMID: 23851932 
 

Pancreas transplantation: in for the long run

Paraskevas S.
Curr Opin Organ Transplant. 2012 Feb;17(1):71-2. 
PMID: 22227721
 

Evidence of endoplasmic reticulum stress mediating cell death in transplanted human islets

Negi S, Park SH, Jetha A, Aikin R, Tremblay M, Paraskevas S.
Cell Transplant. 2012;21(5):889-900. 
PMID: 22182941
 

Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture

Negi S, Jetha A, Aikin R, Hasilo C, Sladek R, Paraskevas S.
PLoS One. 2012;7(1):e30415.
PMID: 22299040
 

Differential expression pattern of ZAC in developing mouse and human pancreas

Du X, Rousseau M, Ounissi-Benkalha H, Marchand L, Jetha A, Paraskevas S, Goodyer C, Polychronakos C.
J Mol Histol. 2011 Apr;42(2):129-36. 
PMID: 21305342 
 

​Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

Grunnet LG, Aikin R, Tonnesen MF, Paraskevas S, Blaabjerg L, Størling J, Rosenberg L, Billestrup N, Maysinger D, Mandrup-Poulsen T.
Diabetes. 2009 Aug;58(8):1807-15. 
PMID: 19470609 
 

Transplantation for type 1 diabetes mellitus. Whole organ or islets?

Vrochides D, Paraskevas S, Papanikolaou V.
Hippokratia. 2009 Jan;13(1):6-8.
PMID: 19240814 
 

​Donor and isolation variables predicting human islet isolation success

Hanley SC, Paraskevas S, Rosenberg L.
Transplantation. 2008 Apr 15;85(7):950-5. 
PMID: 18408573 
 

Autocrine insulin action activates Akt and increases survival of isolated human islets

Aikin R, Hanley S, Maysinger D, Lipsett M, Castellarin M, Paraskevas S, Rosenberg L.
Diabetologia. 2006 Dec;49(12):2900-9. 
PMID: 17053882 
 

​Tumor necrosis factor-alpha production by human islets leads to postisolation cell death

Hanley S, Liu S, Lipsett M, Castellarin M, Rosenberg L, Tchervenkov J, Paraskevas S.
Transplantation. 2006 Sep 27;82(6):813-8.
PMID: 17006329 
 

Inhibition of caspase-mediated PARP-1 cleavage results in increased necrosis in isolated islets of Langerhans

Aikin R, Rosenberg L, Paraskevas S, Maysinger D.
J Mol Med (Berl). 2004 Jun;82(6):389-97. 
PMID: 15105993 
 

​Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody

Hering BJ, Kandaswamy R, Harmon JV, Ansite JD, Clemmings SM, Sakai T, Paraskevas S, Eckman PM, Sageshima J, Nakano M, Sawada T, Matsumoto I, Zhang HJ, Sutherland DE, Bluestone JA.
Am J Transplant. 2004 Mar;4(3):390-401.
PMID: 14961992 
 

Signals for death and differentiation: a two-step mechanism for in vitro transformation of adult islets of Langerhans to duct epithelial structures

Jamal AM, Lipsett M, Hazrati A, Paraskevas S, Agapitos D, Maysinger D, Rosenberg L.
Cell Death Differ. 2003 Sep;10(9):987-96.
PMID: 12934073
 

Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: insulin as an autocrine survival signal

Paraskevas S, Aikin R, Maysinger D, Lakey JR, Cavanagh TJ, Agapitos D, Wang R, Rosenberg L.
Ann Surg. 2001 Jan;233(1):124-33.
PMID: 11141234 
 

Cell loss in isolated human islets occurs by apoptosis

Paraskevas S, Maysinger D, Wang R, Duguid TP, Rosenberg L.
Pancreas. 2000 Apr;20(3):270-6.
PMID: 10766453 
 

​Structural and functional changes resulting from islet isolation lead to islet cell death

Rosenberg L, Wang R, Paraskevas S, Maysinger D.
Surgery. 1999 Aug;126(2):393-8.
PMID: 10455912 
 

Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival

Paraskevas S, Aikin R, Maysinger D, Lakey JR, Cavanagh TJ, Hering B, Wang R, Rosenberg L.
FEBS Lett. 1999 Jul 23;455(3):203-8.
PMID: 10437773 
 

Characterization of integrin expression in islets isolated from hamster, canine, porcine, and human pancreas

Wang RN, Paraskevas S, Rosenberg L.
J Histochem Cytochem. 1999 Apr;47(4):499-506.
PMID: 10082751 
 

Apoptosis occurs in freshly isolated human islets under standard culture conditions

Paraskevas S, Duguid WP, Maysinger D, Feldman L, Agapitos D, Rosenberg L.
Transplant Proc. 1997 Feb-Mar;29(1-2):750-2. 
PMID: 9123509 
 

​Transdifferentiation of human islets to pancreatic ductal cells in collagen matrix culture

Yuan S, Rosenberg L, Paraskevas S, Agapitos D, Duguid WP.
Differentiation. 1996 Oct;61(1):67-75.
PMID: 8921586 
 

Phenotypic transformation of isolated human islets in collagen matrix culture

Yuan S, Paraskevas S, Duguid WP, Rosenberg L.
Transplant Proc. 1995 Dec;27(6):3364. 
PMID: 8539996

 

 

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